Preventing cluster headache attacks with LSD
How to use low-dose LSD to interrupt cluster headache cycles: A widely used busting method with a well-established patient protocol.
Last updated: March 2026
Phase 1: Preparation / Detox
5β7 days before first dose:
- Stop using triptans (e.g., sumatriptan) β May block LSD's effectiveness
- Stop steroids (e.g., prednisone) if safe β Can interfere with LSD's action
- Avoid SSRIs / SNRIs if possible (consult your doctor) β May blunt or block psychedelic effects
- Reduce alcohol and caffeine β Lowers triggers and balances the body
- (Optional) Clear the calendar β Dose days are best spent in a quiet, stress-free environment
Phase 2: First Dose ("Bust #1")
- Pick Day: Choose a day you can rest afterward
- Dose: ~25β50 mcg LSD : Low dose, sub-hallucinogenic for most
- Environment: Quiet, low light, safe space β Promotes comfort and reduces stimulation
- Log: Record dose, duration, and headache effects β Helps track response over time
What to expect:
- Most people do not trip at this dose.
- Possible subtle effects: mood shifts, body sensations, or energy changes.
- Relief may come within 1β24 hours, or gradually over multiple busts.
Phase 3: Repeat Doses ("Busts #2 & #3")
- Day 6 (Bust #2): Same dose or adjust slightly
- Day 11 (Bust #3): If needed, same dose or adjust slightly
- After: Wait and observe. The goal is to break or reduce the attack cycle.
Spacing is critical. LSD tolerance lasts 5β7 days. Dosing too soon will not work.
Many people see their cycle disrupted after 2β3 busts, sometimes staying attack-free for weeks or months.
Maintenance Bust (Optional)
If attacks return:
- Take 1 bust (25β50 mcg) again.
- Only when needed; some people bust just a few times per year.
Safety & Harm Reduction
- Stay hydrated: Headache symptoms can mimic dehydration
- Never bust daily: LSD tolerance builds quickly
- Have a trusted person present: Especially if new to psychedelics
- Rest after busts: Allows the nervous system to reset
- Avoid mixing with prescription meds: Prevents interactions or reduced effectiveness
Example: 3-Bust Calendar
- Aug 7: Begin detox; stop triptans
- Aug 12 (Day 1): Bust #1 (25β50 mcg)
- Aug 17 (Day 6): Bust #2
- Aug 22 (Day 11): Bust #3 (if needed)
- Aug 23βSep: Observe β possible remission period
Measuring Your Dose
- Blotter paper: Know exact mcg per tab; cut carefully
- Example: If 1 tab = 100 mcg β cut into 4 pieces for 25 mcg.
- Liquid LSD: Use syringe/dropper; store dark & cold
- Microdots: Hard to split; less common
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